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tuberous sclerosis complex 2 (tsc2)  (Human Protein Atlas)

 
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    Structured Review

    Human Protein Atlas tuberous sclerosis complex 2 (tsc2)
    Tuberous Sclerosis Complex 2 (Tsc2), supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tuberous+sclerosis+complex+2+(tsc2)/tuberous+sclerosis+complex+2++tsc2+/pm34693742-153-9-0
    Average 90 stars, based on 1 article reviews
    tuberous sclerosis complex 2 (tsc2) - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Biomarker Discovery:

    Article Title: A new view of macula densa cell protein synthesis.
    Article Snippet: .. Human protein atlas (HPA) validation of immunohistochemistry labeling for tuberous sclerosis complex 2 (TSC2; A), DEP domain containing mTOR interacting protein (Deptor; B), ribosomal protein S6 (RPS6) kinase (RPS6K; C), and eukaryotic translation initiation factor 3 C (eIF3C; D) in the human kidney. ..

    Immunohistochemistry:

    Article Title: A new view of macula densa cell protein synthesis.
    Article Snippet: .. Human protein atlas (HPA) validation of immunohistochemistry labeling for tuberous sclerosis complex 2 (TSC2; A), DEP domain containing mTOR interacting protein (Deptor; B), ribosomal protein S6 (RPS6) kinase (RPS6K; C), and eukaryotic translation initiation factor 3 C (eIF3C; D) in the human kidney. ..

    Labeling:

    Article Title: A new view of macula densa cell protein synthesis.
    Article Snippet: .. Human protein atlas (HPA) validation of immunohistochemistry labeling for tuberous sclerosis complex 2 (TSC2; A), DEP domain containing mTOR interacting protein (Deptor; B), ribosomal protein S6 (RPS6) kinase (RPS6K; C), and eukaryotic translation initiation factor 3 C (eIF3C; D) in the human kidney. ..



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    Image Search Results


    Sodium Danshensu regulates TSC2/mTOR pathway. (A,B) Sodium Danshensu showed a dose-dependent increase in TSC2 protein expression; (C) sodium Danshensu further decreased p-mTOR protein expression and p-mTOR/mTOR ratio in astrocytes compared with OGD/R group, the mRNA and proteins were evaluated by qRT-PCR and western blot, respectively. OGD/R, oxygen glucose deprivation/reoxygenation; TSC2, tuberous sclerosis complex-2; mTOR, mammalian target of rapamycin; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; mRNA, messenger RNA; qRT-PCR, quantitative real-time polymerase chain reaction. **P<0.001, showed significant difference; # P<0.01, showed significant difference; ## P<0.05, showed significant difference.

    Journal: Annals of Translational Medicine

    Article Title: Sodium Danshensu protects against oxygen glucose deprivation/reoxygenation-induced astrocytes injury through regulating NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome and tuberous sclerosis complex-2 (TSC2)/mammalian target of rapamycin (mTOR) pathways

    doi: 10.21037/atm-22-2143

    Figure Lengend Snippet: Sodium Danshensu regulates TSC2/mTOR pathway. (A,B) Sodium Danshensu showed a dose-dependent increase in TSC2 protein expression; (C) sodium Danshensu further decreased p-mTOR protein expression and p-mTOR/mTOR ratio in astrocytes compared with OGD/R group, the mRNA and proteins were evaluated by qRT-PCR and western blot, respectively. OGD/R, oxygen glucose deprivation/reoxygenation; TSC2, tuberous sclerosis complex-2; mTOR, mammalian target of rapamycin; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; mRNA, messenger RNA; qRT-PCR, quantitative real-time polymerase chain reaction. **P<0.001, showed significant difference; # P<0.01, showed significant difference; ## P<0.05, showed significant difference.

    Article Snippet: The membranes were then blocked with 5% nonfat milk, then incubated with the respective primary antibodies: NOD-like receptor pyrin domain containing 3 (NLRP3) (cat. no. Ab263899; 1:1,000; Abcam), high mobility group protein B1 (HMGB1) (cat. no. Ab18256; 1:1,000; Abcam), phosphorylated-p65 (p-p65) (cat. no. Ab76302; 1:1,000; Abcam), p65 (cat. no. 8242; 1:1,000; Cell Signaling Technology, Inc. (CST), Danvers, MA, USA), Beclin1 (cat. no. Ab207612; 1:1,000; Abcam), P62 (cat. no. 39749; CST), LC3B (cat. no. Ab192890; 1:1,000; Abcam), tuberous sclerosis complex-2 (TSC2) (cat. no. 3990; 1:1,000; CST), p-mammalian target of rapamycin (mTOR) (cat. no. Ab137133; 1:1,000; Abcam), mTOR (cat. no. Ab134903; 1:1,000; Abcam), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (cat. no. 5174; 1:1,000; CST) for 24 hours at 4 °C.

    Techniques: Expressing, Quantitative RT-PCR, Western Blot, Real-time Polymerase Chain Reaction